Surprisingly, Loqs2 is not present in the genome of other related mosquitoes, which are not vectors of the virus. Researchers deduced that this gene could provide a key to understanding this distinctive feature of Aedes mosquitoes.
Control of dengue virus in the midgut of Aedes aegypti by ectopic expression of the dsRNA-binding protein Loqs2. Roenick P. Olmo, Alvaro G. Ferreira, Tatiane C. Izidoro-Toledo, Eric R. Aguiar, Isaque J. Rocha, Thiago H. Leite, Siad C. Dengue viruses are spread to people through the bites of infected Aedes species mosquitoes Ae.
These are the same types of mosquitoes that spread Zika and chikungunya viruses. Rarely, dengue can be spread through blood transfusion, organ transplant, or through a needle stick injury. Skip directly to site content Skip directly to page options Skip directly to A-Z link. Section Navigation.
There were 37, severe cases and 1, deaths in the hemisphere. Following infection with one serotype, subsequent infection with a different serotype increases a person's risk of severe dengue and death. Only Canada and continental Chile are free from dengue and its vector. Uruguay has no dengue cases, but it does have Ae.
Fact sheet. About Dengue It is transmitted by the bite of a mosquito infected with one of the four serotypes of dengue virus. It is a febrile illness that affects infants, children and adults.
The infection may be asymptomatic, or it may present with symptoms ranging from a moderate fever to a disabling high fever, with severe headache, pain behind the eyes, muscle and joint pain, and rashes. There is no a specific medicine to treat dengue. The disease has a pattern according to the seasons: the majority of cases in the southern hemisphere occur in the first part of the year, and the majority of cases in the northern hemisphere occur in the second half.
Dengue prevention and control must be intersectoral and involve the family and the community. About Aedes aegypti Life cicle. How to eliminate them? What PAHO does. RELDA has now been expanded to include chikungunya and Zika fever and now comprises 32 laboratories in 26 countries of the Region. A tool for the diagnosis and care of patients with suspected arbovirosis dengue, chikungunya and Zika was published in Currently, the first clinical guide for arbovirosis is being developed following the GRADE methodology.
This guide will be published in Detailed Information. Disease phases. Feverish phase Patients develop a sudden, high fever. Critical phase Near the disappearance of the fever, when the temperature drops to Recovery phase When the patient survives the critical phase which does not exceed 48 to 72 hours , they move on to the recovery phase. Revised Dengue Classification The classification recommended by the World Health Organization in is the so-called revised classification, which emerged from the DENCO results, which included almost 2, confirmed cases of dengue from eight countries and two continents and establishes two forms of the Dengue disease and severe dengue.
Differential diagnosis When making the diagnosis, it should be kept in mind that some symptoms can be confused with those of other diseases such as malaria, rubella, measles, typhoid fever, meningitis and influenza.
Laboratory diagnosis The definitive diagnosis of dengue infection is made in the laboratory and depends on the detection of specific antibodies in the patient's serum, detection of viral antigen or viral RNA in serum or tissue, or viral isolation.
Viral isolation: CFour viral isolation systems have been used for dengue virus, intracerebral inoculation of day old mice, mammalian cell culture LLC-MK2 , intrathoracic inoculation of adult mosquitoes and the use of mosquito cell culture. Viral Identification: The method of choice for dengue virus reporting is IFA; serospecific monoclonal antibodies, produced in tissue culture or mouse ascitic fluid and fluorescein-isothiocyanate conjugated IgG.
It is used to detect viral RNA in human clinical samples, autopsy tissue and mosquitoes. It has a similar sensitivity to viral isolation with the advantage that problems in handling, storage and the presence of antibodies do not influence its result. However, it should be emphasized that PCR is not a substitute for viral isolation.
Immunohistochemistry: With immunohistochemical methods, it is possible to detect viral antigen in a wide variety of tissues. These methods involve enzyme conjugation with phosphatases and peroxidases in conjunction with mono- and polyclonal antibodies. Rapid tests: The clinical features of dengue are often nonspecific and therefore require laboratory confirmation. Accurate but sophisticated methods such as virus isolation or polymerase chain reaction RT-PCR require advanced equipment and infrastructure.
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